Michael Grayling

Newcastle University Research Fellow

Population Health Sciences Institute

Biography

Background

I am a Newcastle University Research Fellow in Biostatistics. I have been at Newcastle University since November 2018. Prior to this I was a Statistician at the MRC Biostatistics Unit, University of Cambridge.

I am interested in the design and analysis of clinical trials. My work has involved a mixture of developing novel statistical methodology for trials, comparing existing method performance, and collaborating on real trials. I also work on developing user-friendly software for trial design; I created and maintain the multiarm app for designing fixed-sample and adaptive (group-sequential/drop-the-losers) multi-arm trials, available here.

PhD students

Ruqayya Azher (Primary supervisor: James Wason)
Laura Etfer
Aritra Mukherjee (Primary supervisor: James Wason)
Luke Ouma (Primary supervisor: James Wason)
Samuel Sarkodie

Contact

Email: michael.grayling@ncl.ac.uk
Telephone: +44 (0) 191 208 3699
Address: Population Health Sciences Institute, 4th Floor Ridley Building 1, Queen Victoria Road, Newcastle upon Tyne NE1 7RU, UK

Interests

Adaptive design
Early phase oncology trials
Crossover trials
Stepped-wedge trials

Education

Wellcome Trust PhD Programme in Mathematical Genomics and Medicine, 2012-16
MRC Biostatistics Unit, University of Cambridge
Systems Biology MSci, 2011-12
University of Cambridge
Mathematics BA (Hons), 2008-11
University of Cambridge

Publications

Quickly discover relevant content by filtering publications.

Grayling MJ, Bigirumurame T, Cherlin S, Ouma L, Zheng H, Wason J (2021). Innovative trial approaches in immune-mediated inflammatory diseases: Current use and future potential. BMC Rheumatol 2021; 5:21.

Grayling MJ, Mander AP (2021). Accounting for variation in the required sample size in the design of group-sequential trials. Contemp Clin Trials 2021; 107:106459.

Kunzmann K, Grayling MJ, Lee KM, Robertson DS, Rufibach K, Wason JMS (2021). A review of Bayesian perspectives on sample size derivation for confirmatory trials. Am Stat 2021; DOI:10.1080/00031305.2021.1901782.

Ouma LO, Grayling MJ, Zheng H, Wason J (2021). Treatment allocation strategies for umbrella trials in the presence of multiple biomarkers: A comparison of methods. Pharm Stat 2021; doi:10.1002/pst.2119.

Ward M, Grayling M, Wason J, Welton NJ, Haji-Ali AL, Jalal H, Thom H (2020). PSU4 Value of information for adaptive trials: Proof of concept study in multi-arm multi-stage trials of interventions for the prevention of surgical site infections. Value Health 2020; 23:S738.

McClelland G, Wilson N, Shaw L, Grayling M, Haworth D, Price CI (2020). Ambulance documentation of stroke symptoms during the UK COVID-19 'Stay at Home' message. Emerg Med J 2020; 38:83-84.

McClelland G, Shaw G, Thompson L, Wilson N, Grayling M (2020). Impact of the COVID-19 lockdown on hangings attended by emergency medical services. Resuscitation 2020; 157:89-90.

Law M, Grayling MJ, Mander AP (2020). A stochastically curtailed two-arm randomised phase II trial design for binary outcomes. Pharm Stat 2020; 20:212-28.

McMenamin M, Grayling MJ, Berglind A, Wason JMS (2020). Increasing power in the analysis of responder endpoints in rheumatology: a software tutorial. medRxiv 2020.

Grayling MJ, Wheeler GM (2020). A review of available software for adaptive clinical trial design. Clin Trials 2020;17:323-31.

Grayling MJ, Wason JMS (2020). A web application for the design of multi-arm clinical trials. BMC Cancer 2020; 20:80.

Wych J, Grayling MJ, Mander AP (2019). Sample size re-estimation in crossover trials: Application to the AIM HY-INFORM study. Trials 2019;20:665.

Grayling MJ, Mander AP, Wason JMS (2019). Two-stage adaptive designs for three-treatment bioequivalence studies. Stat Biopharm Res 2019; 11:360-74.

Grayling MJ, Dimairo M, Mander AP, Jaki TF (2019). A review of perspectives on the use of randomization in phase II oncology trials. JNCI: J Natl Cancer I 2019; 111:1255-62.

DOI .bib .enw .ris

Grayling MJ, Wason JMS, Mander AP (2019). Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Commun Stat Theory.

DOI .bib .enw .ris

Grayling MJ, Mander AP, Wason JMS (2019). Admissible multiarm stepped‐wedge cluster randomized trial designs. Stat Med 2019; 38:1103-19.

DOI .bib .enw .ris

Grayling MJ, Mander AP (2019). Re-formulating Gehan's design as a flexible two-stage single-arm trial. BMC Med Res Methodol 2019; 19:22.

DOI .bib .enw .ris

Grayling MJ, Mander AP (2018). Calculations involving the multivariate normal and multivariate t distributions with and without truncation. Stata J 2018; 18:826-43.

DOI .bib .enw .ris

Grayling MJ, Wason JMS, Mander AP (2018). Group sequential crossover trial designs with strong control of the familywise error rate. Sequential Anal 2018; 37:174-203.

DOI .bib .enw .ris

See all publications