Michael Grayling

Newcastle University Research Fellow

Population Health Sciences Institute

Biography

Background

I am a Newcastle University Research Fellow in Biostatistics. I have been at Newcastle University since November 2018. Prior to this I was a statistician at the MRC Biostatistics Unit, University of Cambridge.

I am interested in the design and analysis of clinical trials. My work has involved a mixture of developing novel statistical methodology for trials, comparing existing method performance, and collaborating on real trials. I also work on developing user-friendly software for trial design; I created and maintain the multiarm app for designing fixed-sample and adaptive (group-sequential/drop-the-losers) multi-arm trials, available here.

PhD students

Ruqayya Azher (Primary supervisor: James Wason)
Laura Etfer
Aritra Mukherjee (Primary supervisor: James Wason)
Luke Ouma (Primary supervisor: James Wason)
Samuel Sarkodie

Contact

Email: michael.grayling@ncl.ac.uk
Telephone: +44 (0) 191 208 3699
Address: Population Health Sciences Institute, 4th Floor Ridley Building 1, Queen Victoria Road, Newcastle upon Tyne NE1 7RU, UK

Interests

Adaptive design
Early phase oncology trials
Crossover trials
Stepped-wedge trials

Education

Wellcome Trust PhD Programme in Mathematical Genomics and Medicine, 2012-16
MRC Biostatistics Unit, University of Cambridge
Systems Biology MSci, 2011-12
University of Cambridge
Mathematics BA (Hons), 2008-11
University of Cambridge

Publications

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Michael J. Grayling, Adrian P. Mander (2021). Two-Stage Single-Arm Trials Are Rarely Analyzed Effectively or Reported Adequately. JCO Precision Oncology.

Grayling MJ, Bigirumurame T, Cherlin S, Ouma L, Zheng H, Wason J (2021). Innovative trial approaches in immune-mediated inflammatory diseases: Current use and future potential. BMC Rheumatol 2021; 5:21.

Grayling MJ, Mander AP (2021). Accounting for variation in the required sample size in the design of group-sequential trials. Contemp Clin Trials 2021; 107:106459.

Kunzmann K, Grayling MJ, Lee KM, Robertson DS, Rufibach K, Wason JMS (2021). A review of Bayesian perspectives on sample size derivation for confirmatory trials. Am Stat 2021; DOI:10.1080/00031305.2021.1901782.

Ouma LO, Grayling MJ, Zheng H, Wason J (2021). Treatment allocation strategies for umbrella trials in the presence of multiple biomarkers: A comparison of methods. Pharm Stat 2021; doi:10.1002/pst.2119.

Ward M, Grayling M, Wason J, Welton NJ, Haji-Ali AL, Jalal H, Thom H (2020). PSU4 Value of information for adaptive trials: Proof of concept study in multi-arm multi-stage trials of interventions for the prevention of surgical site infections. Value Health 2020; 23:S738.

McClelland G, Wilson N, Shaw L, Grayling M, Haworth D, Price CI (2020). Ambulance documentation of stroke symptoms during the UK COVID-19 'Stay at Home' message. Emerg Med J 2020; 38:83-84.

McClelland G, Shaw G, Thompson L, Wilson N, Grayling M (2020). Impact of the COVID-19 lockdown on hangings attended by emergency medical services. Resuscitation 2020; 157:89-90.

Law M, Grayling MJ, Mander AP (2020). A stochastically curtailed two-arm randomised phase II trial design for binary outcomes. Pharm Stat 2020; 20:212-28.

McMenamin M, Grayling MJ, Berglind A, Wason JMS (2020). Increasing power in the analysis of responder endpoints in rheumatology: a software tutorial. medRxiv 2020.

Grayling MJ, Wheeler GM (2020). A review of available software for adaptive clinical trial design. Clin Trials 2020;17:323-31.

Grayling MJ, Wason JMS (2020). A web application for the design of multi-arm clinical trials. BMC Cancer 2020; 20:80.

Wych J, Grayling MJ, Mander AP (2019). Sample size re-estimation in crossover trials: Application to the AIM HY-INFORM study. Trials 2019;20:665.

Grayling MJ, Mander AP, Wason JMS (2019). Two-stage adaptive designs for three-treatment bioequivalence studies. Stat Biopharm Res 2019; 11:360-74.

Grayling MJ, Dimairo M, Mander AP, Jaki TF (2019). A review of perspectives on the use of randomization in phase II oncology trials. JNCI: J Natl Cancer I 2019; 111:1255-62.

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Grayling MJ, Wason JMS, Mander AP (2019). Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Commun Stat Theory.

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Grayling MJ, Mander AP, Wason JMS (2019). Admissible multiarm stepped‐wedge cluster randomized trial designs. Stat Med 2019; 38:1103-19.

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Grayling MJ, Mander AP (2019). Re-formulating Gehan's design as a flexible two-stage single-arm trial. BMC Med Res Methodol 2019; 19:22.

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Grayling MJ, Mander AP (2018). Calculations involving the multivariate normal and multivariate t distributions with and without truncation. Stata J 2018; 18:826-43.

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