James Wason

James Wason

Professor of Biostatistics

Population Health Sciences Institute

Biography

Background

I am a statistician with interests in methods for improving the design and analysis of clinical trials. As well as working in methodology development I have a great interest in collaborating on real trials to apply new methods in practice.

I have been at Newcastle University since July 2017.

Areas of expertise

  • Biostatistics
  • Clinical trials
  • Novel trial design

Research

My research focuses on statistical methods for improved design and analysis of clinical trials. I am particularly interested in:

  1. Adaptive designs for clinical trials;
  2. Methods for incorporating biomarkers into clinical trials to stratify patients by treatment response;
  3. Improved methods for analysing composite endpoints, in particular ones with continuous components.

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Contact

Publications

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Aritra Mukherjee, Michael J. Grayling, James M. S. Wason (2022). Adaptive Designs: Benefits and Cautions for Neurosurgery Trials. World Neurosurgery.

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Aritra Mukherjee, James M. S. Wason, Michael J. Grayling (2022). When is a two-stage single-arm trial efficient? An evaluation of the impact of outcome delay. European Journal of Cancer.

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Guy S. Taylor, Andy C. Shaw, Kieran Smith, James Wason, Timothy J. McDonald, Richard A. Oram, Emma Stevenson, James A. M. Shaw, Daniel J. West (2022). Capturing the real-world benefit of residual $p̆beta$-cell function during clinically important time-periods in established Type 1 diabetes. Diabetic Medicine.

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Vivien Li, Baptiste Leurent, Frederik Barkhof, Marie Braisher, Fay Cafferty, Olga Ciccarelli, Arman Eshaghi, Emma Gray, Jennifer M. Nicholas, Mahesh Parmar, Guy Peryer, Jenny Robertson, Nigel Stallard, James Wason, Jeremy Chataway (2022). Designing Multi-arm Multistage Adaptive Trials for Neuroprotection in Progressive Multiple Sclerosis. Neurology.

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Amanda D Busby, James Wason, Arthur G Pratt, Adam Young, John D Isaacs, Elena Nikiphorou (2022). The role of comorbidities alongside patient and disease characteristics on long-term disease activity in RA using UK inception cohort data. Rheumatology.

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Michael J. Grayling, Martina McMenamin, Robert Chandler, Rakesh Heer, James M. S. Wason (2022). Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials. BMC Cancer.

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Michael J. Grayling, James M. S. Wason, Sofía S. Villar (2022). Response adaptive intervention allocation in stepped-wedge cluster randomized trials. Statistics in Medicine.

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Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason (2021). Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine.

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Marco Egle, Saima Hilal, A M Tuladhar, Lukas Pirpamer, Edith Hofer, Marco Duering, James Wason, Robin G Morris, Martin Dichgans, Reinhold Schmidt, Daniel Tozer, Christopher Chen, Frank-Erik de Leeuw, Hugh S Markus (2021). Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration. Journal of Neurology, Neurosurgery & Psychiatry.

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Busby AD, Wason J, Pratt AG, Young A, Isaacs JD, Nikiphorou E (2021). Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?. Rheumatology 2021; DOI:10.1093/rheumatology/keab598.

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Grayling MJ, Bigirumurame T, Cherlin S, Ouma L, Zheng H, Wason J (2021). Innovative trial approaches in immune-mediated inflammatory diseases: Current use and future potential. BMC Rheumatol 2021; 5:21.

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Cherlin S, Wason JMS (2021). Developing a predictive signature for two trial endpoints using the cross-validated risk scores method. Biostatistics 2021; DOI: 10.1093/biostatistics/kxaa055.

Collins A, Lendrem D, Wason J, Tarn J, Howard-Tripp N, Bodewes I, Versnel MA, Gottenberg JE, Seror R, Mariette X, Ng WF (2021). Revisiting the JOQUER trial: Stratification of primary Sjögren's syndrome and the clinical and interferon response to hydroxychloroquine. Rheumatol Int 2021; 41:1593-1600.

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Kunzmann K, Grayling MJ, Lee KM, Robertson DS, Rufibach K, Wason JMS (2021). A review of Bayesian perspectives on sample size derivation for confirmatory trials. Am Stat 2021; DOI:10.1080/00031305.2021.1901782.

Vergis N, Phillips R, Cornelius V, Katsarou A, Youngstein T, Cook L, Willicombe M, Pilay C, Shturova T, Almonte M, Charania A, Turner R, Kon OM, Cooke G, Thursz M, Cherlin S, Wason J, Milojkovic D, Innes AJ, Cooper N (2021). Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: A structured summary of a study protocol for a randomised controlled trial. Trials 2021; 22:270.

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Ouma LO, Grayling MJ, Zheng H, Wason J (2021). Treatment allocation strategies for umbrella trials in the presence of multiple biomarkers: A comparison of methods. Pharm Stat 2021; doi:10.1002/pst.2119.

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Lee KM, Brown LC, Jaki T, Stallard N, Wason J (2021). Statistical consideration when adding new arms to ongoing clinical trials: The potentials and the caveats. Trials 2021; 22:203.

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Fonagy P, Yakeley J, Gardner T, Simes E, McMurran M, Moran P, Crawford M, Frater A, Barrett B, Cameron A, Wason J, Pilling S, Butler S, Bateman A (2020). Mentalization for Offending Adult Males (MOAM): Study protocol for a randomized controlled trial to evaluate mentalization-based treatment for antisocial personality disorder in male offenders on community probation. Trials 2020; 21:1001.

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Ward M, Grayling M, Wason J, Welton NJ, Haji-Ali AL, Jalal H, Thom H (2020). PSU4 Value of information for adaptive trials: Proof of concept study in multi-arm multi-stage trials of interventions for the prevention of surgical site infections. Value Health 2020; 23:S738.

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Witham MD, Anderson E, Carroll CB, Dark PM, Down K, Hall AS, Knee J, Maher ER, Maier RH, Mountain GA, Nestor G, O'Brien JT, Oliva L, Wason J, Rochester L (2020). Ensuring that COVID-19 research is inclusive: Guidance from the NIHR INCLUDE project. BMJ Open 2020; 10:e043634.

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