James Wason

Professor of Biostatistics

Population Health Sciences Institute


I am a statistician with interests in methods for improving the design and analysis of clinical trials. As well as working in methodology development I have a great interest in collaborating on real trials to apply new methods in practice.

I have been at Newcastle University since July 2017. I currently retain a part-time position in the MRC Biostatistics Unit, University of Cambridge.

Areas of expertise

  • Biostatistics
  • Clinical trials
  • Novel trial design


My research focuses on statistical methods for improved design and analysis of clinical trials. I am particularly interested in:

  1. Adaptive designs for clinical trials;
  2. Methods for incorporating biomarkers into clinical trials to stratify patients by treatment response;
  3. Improved methods for analysing composite endpoints, in particular ones with continuous components.

Scopus: Click here



You can quickly discover relevant content by members of the PHSI-BRG by filtering publications here.

Design of Multi-Arm, Multi-Stage Trials in Oncology

In Textbook of Clinical Trials in Oncology: A Statistical Perspective

Design of experiments for a confirmatory trial of precision medicine

Journal of Statistical Planning and Inference 2019; 199:179-187

Multi-Arm Multi-Stage Designs for Clinical Trials with Treatment Selection

In Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects

Design of telehealth trials – Introducing adaptive approaches

International Journal of Medical Informatics 2014; 83(12):870-880

Recent Developments in Group-Sequential Designs

In Developments in Statistical Evaluation of Clinical Trials 97-118

Some recommendations for multi-arm multi-stage trials

Statistical Methods in Medical Research 2012; 25(2):716-727

Optimal design of multi-arm multi-stage trials

Statistics in Medicine 2012; 31(30):4269-4279

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Nature 2011; 476(7359):214-219