Publications

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Design of experiments for a confirmatory trial of precision medicine

Journal of Statistical Planning and Inference 2019; 199:179-187

What is an ROC curve?

Emergency Medicine Journal 2017; 34(6):357-359

A multi-stage drop-the-losers design for multi-arm clinical trials.

Multi-arm multi-stage trials can improve the efficiency of the drug development process when multiple new treatments are available for …

Scientific Publishing: Transparent reporting of research results in $backslash$textiteLife

Manuscripts should include all the experimental and statistical details that are needed to replicate the experiments and analyses …

Some recommendations for multi-arm multi-stage trials.

Multi-arm multi-stage designs can improve the efficiency of the drug-development process by evaluating multiple experimental arms …

A review of statistical designs for improving the efficiency of phase II studies in oncology

Phase II oncology trials are carried out to assess whether an experimental anti-cancer treatment shows sufficient signs of …

Improving the power of clinical trials of rheumatoid arthritis by using data on continuous scales when analysing response rates: an application of the augmented binary method

Objective. In clinical trials of RA, it is common to assess effectiveness using end points based upon dichotomized continuous measures …

The potential of adaptive design in animal studies

International Journal of Molecular Sciences 2015; 16(10):24048–24058

Design of telehealth trials – Introducing adaptive approaches

International Journal of Medical Informatics 2014; 83(12):870-880

Correcting for multiple-testing in multi-arm trials: is it necessary and is it done?

BACKGROUND: Multi-arm trials enable the evaluation of multiple treatments within a single trial. They provide a way of substantially …

Adaptive designs for clinical trials assessing biomarker-guided treatment strategies.

Background:: The Biomarker Strategy Design has been proposed for trials assessing the value of a biomarker in guiding treatment in …

A comparison of Bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials

When several experimental treatments are available for testing, multi-arm trials provide gains in efficiency over separate trials. …

An optimal multi-period crossover design for an application in paediatric nephrology

Crossover clinical trials can provide substantial benefits by eliminating inter-patient variation from treatment comparisons and by …

Dropout in crossover and longitudinal studies: Is complete case so bad?

We discuss inference for longitudinal clinical trials subject to possibly informative dropout. A selection of available methods is …

Linkage analysis and the study of Mendelian disease in the era of whole exome and genome sequencing

Whole exome and whole genome sequencing are now routinely used in the study of inherited disease, and some of their major successes …

Recent Developments in Group-Sequential Designs BT - Developments in Statistical Evaluation of Clinical Trials

In a group-sequential trial, patients are recruited in groups, and their response to treatment is assessed. After each group is …

Planning multi-arm screening studies within the context of a drug development program.

Screening trials are small trials used to decide whether an intervention is sufficiently promising to warrant a large confirmatory …

Using continuous data on tumour measurements to improve inference in phase II cancer studies

In phase II cancer trials, tumour response is either the primary or an important secondary endpoint. Tumour response is a binary …

A General Framework for Two-Stage Analysis of Genome-wide Association Studies and Its Application to Case-Control Studies

Two-stage analyses of genome-wide association studies have been proposed as a means to improving power for designs including …

Optimal design of multi-arm multi-stage trials

In drug development, there is often uncertainty about the most promising among a set of different treatments. Multi-arm multi-stage …

Optimal multistage designs for randomised clinical trials with continuous outcomes

Multistage designs allow considerable reductions in the expected sample size of a trial. When stopping for futility or efficacy is …

The choice of test in phase II cancer trials assessing continuous tumour shrinkage when complete responses are expected

Traditionally, phase II cancer trials test a binary endpoint formed from a dichotomisation of the continuous change in tumour size. …

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Nature 2011; 476(7359):214-219

Comparing Methods for Mapping cis Acting Polymorphisms Using Allelic Expression Ratios

Genome wide association studies frequently reveal associations between disease susceptibility and polymorphisms outside coding regions. …

Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia

Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies …

An Expectation-Maximization Algorithm for the Analysis of Allelic Expression Imbalance

A significant proportion of the variation between individuals in gene expression levels is genetic, and it is likely that these …

Genetic linkage studies

SummaryLinkage analysis is used to map genetic loci by use of observations of related individuals. We provide an introduction to …

Optimal designs for Michaelis–Menten kinetic studies

Abstract Many reactions in enzymology are governed by the Michaelis–Menten equation. Characterising these reactions requires the …

Statistical method for the estimation of cerebral blood flow using the Kety$backslash$textendashSchmidt technique

The Kety$backslash$textendashSchmidt technique for the measurement of cerebral blood flow (CBF) has been in use for many years, but …

Alternative criteria for optimal designs of limiting dilution assays

Abstract It is well known that criteria for optimal non-linear designs usually depend on the unknown value of parameters. An …

A FORMULA FOR THE PROBABILITY OF DISCORDANT CLASSIFICATION IN METHOD COMPARISON STUDIES

Abstract Method comparison studies are often reported in terms of the ‘limits of agreement’ between the methods. Many clinical …

Measuring blood glucose in neonatal units: How does hemocue compare?

Archives of Disease in Childhood - Fetal and Neonatal Edition 1996; 75(3):F202-F208

Small clinical trials: Are they all bad?

Abstract Statistician have long argued that randomized controlled trials should be sufficiently large to achieve their purpose, and for …

An Application of Bradley-Terry-Type Models to the Measurement of Pain

SUMMARY A case-study concerning the measurement of pain experienced in the administration of routine subcutaneous injections to …

Multi-period crossover trials

This paper presents a review of crossover designs for use in medical applications which have three or more treatment periods. Only …

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic …

A refinement to the analysis of serial data using summary measures

Abstract A widely used method for the analysis of data collected serially over time is to reduce the data on each subject to a single …

An investigation of changepoints in the annual number of cases of haemolytic uraemic syndrome

Journal of the Royal Statistical Society: Series C (Applied Statistics) 1993; 42(3):461-471

Robust Methods in the Assessment of Multivariate Normality

SUMMARY Royston (1983) extended the Shapiro–Wilk W-test of Normality to the multivariate case and analysed several datasets. This note …