Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?


The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni cancer family syndrome.

Cancer Genetics and Cytogenetics 1989; 42(2):221-226