Overview
The PHSI-BRG are involved in a large number of projects, predominantly clinical trials, covering a wide range of disease areas. Examples of recent and on-going projects are given below.
Selected projects
AIMM
Randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in patients with mitochondrial myopathy
ALTAR
ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women
AnTIC
Phase three randomised control trial of continuous low-dose antibiotic prohylaxis for adults with repeated urinary tract infections
COMBIVAS
A randomised, double-blind, controlled mechanistic study of rituximab and belimumab combination therapy in PR3 ANCA-associated vasculitis
CONFORM-OH
A comparison of fludrocortisone, midodrine or usual care to treat orthostatic hypotension a multi-arm multi-stage randomised controlled trial
DMD Heart
Double-blind randomised multi-centre, placebo-controlled trial of combined ACE-inhibitor and beta-blocker therapy in males with Duchenne muscular dystrophy
Do-Well
Pragmatic trial of domiciliary welfare rights service for older people
Eggcell
Trial of egg recovery rates for IVF using a collection chamber
EMPOWER
2x2 factorial placebo controlled trial of ondansetron and metoclopramide in women with hyperemesis gravidarum
FAB
Feasibility RCT of family focused treatment for adolescents with bi-polar disorder
FiCTION
Multi-centre, three-arm, parallel group, patient randomised controlled trial of three treatment strategies in 3-7 year-old children with caries in primary teeth
MABSC
A platform clinical trial approach to the management of Mycobacterium abscessus complex
MCDS
Two-stage open-label, single arm phase I/IIa trial of carbamazepine in children with skeletal dysplasia
MultICath
Phase 2 non-inferiority RCT investigating a mixed (multi/single-use) catheter management package for users of intermittent catheters
NAIROS
RCT of surgical and medical management of nasal airway obstruction
NATTINA
A multi-centre, randomised, controlled surgical trial of tonsillectomy versus conservative management in frequent sore throat
OPTIMISM
Optimal surveillance strategies for AJCC stage I cutaneous melanoma post primary tumour excision - An evidence synthesis and economic evaluation
PRE-OP BIRDS
Pilot RCT of preoperative behavioural intervention to reduce drinking before elective orthopaedic surgery
PSORT
Psoriasis Stratification to Optimise Relevant Therapy
RATULS
Robot Assisted Training and physiotherapy for Upper Limb deficiency after Stroke
RiGD
Phase 2 trial of rituximab for young patients with Graves' Disease.
RITPBC
Phase two trial of Rituximab for treatment of Primary Biliary Cholangitis
SEED
Pilot trial of end of life care in patients with dementia
SENIOR-RITA
Phase three randomised trial comparing invasive and conservative treatment strategies in older patients with non-ST elevation myocardial infarction
SETS aHUS
Multicentre, open label, prospective, single arm study of the safety and impact of eculizumab withdrawal in patients with atypical haemolytic uraemic syndrome
SIPS JR-HIGH
Multicentre RCT of screening and brief alcohol intervention in young people
SOLID
Feasibility study of interventions to supporting Looked After Children in decreasing drugs and alcohol use
TOPPITS
Trial of Proton Pump Inhibitors in Throat Symptoms
TRAFIC
Targeting the Rheumatoid Arthritis synovial fibroblast via cyclin dependent kinase inhibition
TUBE
Gastrostomy versus nasogastric tube feeding for chemoradiation patients with head and neck cancer
UK-PBC
Stratified Medicine In Primary Biliary Cholangitis
VARIANT
Multicentre feasibility study of biomarker-guided personalised treatment in advanced prostate cancer
VIOLET
Visually Impaired OLder people’s Exercise programme for falls prevenTion
WIRE
WIndow-of-opportunity clinical trial platform for evaluation of novel treatment strategies in REnal cell cancer
LiTEFORM
Lite Therapy Effectiveness For ORal Mucositis